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From the Lake to You - Great Migraine Reading

July 24th, 2008

This is where I am now as I write you.  A beautiful lake in the mountains, where I come every year with a group of friends and extended family, and hike, swim, kayak, and rock on rocking chairs on a  big porch overlooking the lake.  So why am I writing now?  For one thing, it’s been pouring much of the week!  For another, I spent yesterday in my room with a migraine.  A friend posted this link to a Scientific American article on Migraine disease, and I wanted to share it.  She called herself a nerd for having a Scientific American subscription; I guess that makes me a real Migraine Geek for choosing this for my vacation reading!  But it’s really fascinating!

Here’s the link to the article, which explains and summarizes new research into how migraines actually start in the brain and central nervous system: Why Migraines Strike. It’s a long article, but well worth reading
to better understand what is going on in our brains, and new possibilities for treatment. I think the most important point, made by the authors in the last paragraph, is that the evidence is overwhelming that this is a real, congenital disease, a significant difference in brain function. Wave this article in the face of those who still won’t believe Migraine is a disease! A few points that really struck me:

• There is strong evidence suggesting that the tendency to Migraine is genetic, but there are a number of different genes involved, and the same genes are not involved for every migraineur. This may provide some explanation of the wide variety of symptoms experienced by different migraineurs and the variance in effectiveness of treatments from one person to another.
• The differences between migraine with and without aura may be explained by a phenomenon called cortical spreading depression, an abnormal kind of neuronal activity, which moves across the brain like a storm, affecting visual centers in some, motor centers in others, and perhaps even explaining the irritability, sleepiness and brain-fog experienced by those without aura, as the brain centers involved come under the “storm.”  Thus the pro-drome symptoms experienced by those of us without aura may be another kind of aura!
• Triptan drugs, which constrict blood vessels (which is why they are contraindicated for many with heart conditions or high blood pressure), were created when the prevailing theory of the cause of Migraine was vascular.  Luckily, they also inhibit the neuronal activity which is the actual culprit!  However, the new understandings of Migraine as a neurological condition makes development of newer, more specific abortive drugs possible, and several are under development.

Read the article and let me know what you think.  A few of my non-migraineur friends and relations up here even found it interesting.  More fodder for helping others - and ourselves - understand!

See you!  I’ll be heading out on the lake - as soon as it stops raining!

- Megan

Tags: cortical spreading depression, genetics, migraine aura, Migraine disease, Scientific American, vacation
Posted in Medicine, Science | Comments (2)

2 Responses to “From the Lake to You - Great Migraine Reading”

1. Kelly FlywithHope Says:
   July 24th, 2008 at 3:41 pm

   Megan, Great synopsis! Thanks for sharing. I linked this blog on mine.

2. Rain Gem Says:
   July 25th, 2008 at 12:59 am

   Hehe, that’s kinda funny though, how it works… When they tried LCD (triptans) to treat migraines, they had no clue why it was helping. So, they just used one of the side-effects - constricting blood vessels - to explain the “whys”.

   And the funniest bit is, they still develop the abortives that do the exact same thing - constrict blood vessels in the head. Take Telcagepant for example. It’s calcitonin gene-related peptide antagonist. In simple words, it uses calcium to constrict blood vessels. But, since the theory of migraine is neurological now, they try to wiggle out by speculating how it also “might” inhibit nociceptive activity and trigeminocervical complex.

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